BDBM350868 UNC1670A::US10004755, Compound UNC1670A::US9795606, B29

SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCOCC1

InChI Key InChIKey=VEFDEIILCRXHNC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 350868   

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350868(US9795606, B29 | UNC1670A | US10004755, Compound U...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350868(US9795606, B29 | UNC1670A | US10004755, Compound U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350868(US9795606, B29 | UNC1670A | US10004755, Compound U...)
Affinity DataIC50: 57nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350868(US9795606, B29 | UNC1670A | US10004755, Compound U...)
Affinity DataIC50: 67nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350868(US9795606, B29 | UNC1670A | US10004755, Compound U...)
Affinity DataIC50: 250nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent