BDBM350860 UNC2370A::US10004755, Compound UNC2370A::US9795606, B19

SMILES O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12

InChI Key InChIKey=IAURWWSIIMOBHU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 350860   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350860(US9795606, B19 | UNC2370A | US10004755, Compound U...)
Affinity DataIC50: 2nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350860(US9795606, B19 | UNC2370A | US10004755, Compound U...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350860(US9795606, B19 | UNC2370A | US10004755, Compound U...)
Affinity DataIC50: 68nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350860(US9795606, B19 | UNC2370A | US10004755, Compound U...)
Affinity DataIC50: 100nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
University of North Carolina at Chapel Hill

US Patent
LigandPNGBDBM350860(US9795606, B19 | UNC2370A | US10004755, Compound U...)
Affinity DataIC50: 250nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent