BDBM50057465 3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic acid {3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-amide::CHEMBL278865::Upidosin

SMILES COc1ccccc1N1CCN(CCCNC(=O)c2cccc3c2oc(c(C)c3=O)-c2ccccc2)CC1

InChI Key InChIKey=DUCNHKDCVVSJLG-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50057465   

TargetAlpha-1A adrenergic receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of [3H]-prazosin binding to cloned human Alpha-1A adrenergic receptor in CHO-cells (chinese hamster ovary cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataKi:  1nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1D adrenergic receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO-cells (chinese hamster ovary cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]-prazosin binding to cloned human Alpha-1B adrenergic receptor in CHO-cells (chinese hamster ovary cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor serotonergic receptor in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50:  24nMAssay Description:Binding affinity was tested on CEC-pretreated rat liver Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057465(3-Methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylic a...)
Affinity DataIC50:  2nMAssay Description:Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed