BDBM50314071 2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide::CHEMBL1090090::VX-702

SMILES NC(=O)N(c1ccc(C(N)=O)c(n1)-c1ccc(F)cc1F)c1c(F)cccc1F

InChI Key InChIKey=FYSRKRZDBHOFAY-UHFFFAOYSA-N

Data  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50314071   

TargetMitogen-activated protein kinase 14(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 11(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  17nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivin receptor type-2B(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  92nMAssay Description:Binding affinity to ACVR2betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphatidylinositol 4-kinase beta(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to PIK4CbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 10(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  780nMAssay Description:Binding affinity to JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 9(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  2.60E+3nMAssay Description:Binding affinity to JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase NLK(Human)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50314071(2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ur...)
Affinity DataKd:  160nMAssay Description:Binding affinity to NLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed