BDBM50663478 3-PYRIDINECARBOXAMIDE, N-((1,3-DIMETHYL-1H-PYRAZOL-4-YL)SULFONYL)-6-(3-(3,3,3-TRIFLUORO-2,2-DIMETHYLPROPOXY)-1H-PYRAZOL-1-YL)-2-((4S)-2,2,4-TRIMETHYL-1-PYRROLIDINYL)-::Elexacaftor::Elexacaftor component of trikafta::VX-445::Vx-445

SMILES Cc1nn(C)cc1S(=O)(=O)NC(=O)c1ccc(-n2ccc(OCC(C)(C)C(F)(F)F)n2)nc1N1C[C@@H](C)CC1(C)C

InChI Key InChIKey=MVRHVFSOIWFBTE-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50663478   

LigandChemical structure of BindingDB Monomer ID 50663478BDBM50663478(Elexacaftor | Vx-445 | 3-PYRIDINECARBOXAMIDE, N-((...)
Affinity DataEC50:  70nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed