BDBM464030 US10787435, Example 013::WX013

SMILES CC(C)n1cnnc1-c1cccc(n1)-n1cnc2ccc(cc2c1=O)-n1cnc(c1)C1CC1

InChI Key InChIKey=UUFGYUFAPLFHQI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 464030   

LigandPNGBDBM464030(WX013 | US10787435, Example 013)
Affinity DataIC50: 11nMAssay Description:Inhibition of ASK1 (unknown origin) preincubated with compound for 30 mins followed by ATP addition and measured after 120 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM464030(WX013 | US10787435, Example 013)
Affinity DataIC50: 50nMAssay Description:Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent