BDBM50468263 Sepantronium Bromide::YM 155::YM-155

SMILES COCC[n+]1c(C)n(Cc2cnccn2)c2c1C(=O)c1ccccc1C2=O

InChI Key InChIKey=OTSOOHRUMBRSHZ-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50468263   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
University of Toledo College of Medicine and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RIPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of survivin in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 3nMAssay Description:Inhibition of survivin in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of survivin in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin enhancer-binding factor 3(Homo sapiens)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to ILF3 (unknown origin) assessed as dissociation constant at upto 1 uM by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of survivin in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTranscription factor Sp1(Human)
University of Toledo College of Medicine and Life Sciences

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 8nMAssay Description:Inhibition of human SP1 transfected in PC-3 cells by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of survivin in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBaculoviral IAP repeat-containing protein 5(Human)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 14nMAssay Description:Inhibition of survivin in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 500nMAssay Description:Inhibition of PAK1 in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 papain-like protease (1564 to 1878 residues) expressed in Escherichia coli Rosetta (DE3) using Arg-Leu-Arg-Gly-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details Article
PubMed