BDBM86249 ZD 6169::ZD-6169

SMILES C[C@](O)(C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(F)(F)F

InChI Key InChIKey=LVEDGSIMCSQNNX-INIZCTEOSA-N

Data  2 KI  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 86249   

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataKi:  451nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataKi:  630nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  437nMAssay Description:Channel opening activity at human bladder Kir6.2 channel containing SUR2B expressed in L cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataIC50:  9.30E+3nMAssay Description:In vitro inhibitory activity against Pyruvate dehydrogenase kinase by primary enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  1.35E+3nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  295nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  2.75E+3nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  398nMAssay Description:In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Human)
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM86249(ZD 6169 | ZD-6169)
Affinity DataEC50:  8.30E+3nMAssay Description:In vivo inhibion of pyruvate dehydrogenase kinase, increased oxidation of lactateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed