BDBM50033110 ALFUZOSIN::CHEMBL709::N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide

SMILES COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1

InChI Key InChIKey=WNMJYKCGWZFFKR-UHFFFAOYSA-N

Data  8 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50033110   

TargetAlpha-1B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity against Alpha-1B adrenergic receptor from human cloneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1D adrenergic receptor(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from rat clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1D adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity against Alpha-1D adrenergic receptor, from human clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity against Alpha-1A adrenergic receptor from human cloneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  12nMAssay Description:Binding affinity against Alpha-1B adrenergic receptor from hamster clones.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Bovine)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataKi:  23nMAssay Description:Binding affinity against Alpha-1A adrenergic receptor from bovine cloneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.49E+4nMAssay Description:In vitro inhibition of farnesyl-protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Human)
Prin. K. M. Kundnani College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  18nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonW...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.26E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.26E+5nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.58E+6nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily D member 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Panjab University

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at Adrenergic alpha-1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank


TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed