BDBM50003655 Phenytoin
SMILES O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
InChI Key InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50003655
Affinity DataKi: 6.00E+3nMAssay Description:Binding affinity towards cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Binding affinity was measured on Cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+4nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NaV1.2 expressed in HEK cells at -60 mV holding potential by patch clamp recording techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of [3H]-BTX binding to guinea pig voltage-dependent sodium channelMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human voltage-gated sodium channel 1.7 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of partially purified calf lens aldose reductaseMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of bovine liver DHFR assessed as NADPH consumption during conversion of dihydrofolic acid to tetrahydrofolic acidMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human voltage-gated sodium channel 1.5 expressed in HEK293 cells assessed as changes in membranre potential after 45 mins by FRET analy...More data for this Ligand-Target Pair