BDBM50004000 (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate::Antilirium::CHEMBL94::Eserine::Physostol::physostigmine
SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1
InChI Key InChIKey=PIJVFDBKTWXHHD-HIFRSBDPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 132 hits for monomerid = 50004000
Affinity DataKi: 34nMAssay Description:Time dependent inhibition of Electric eel AChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Time dependent inhibition of equine serum BChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Tested for in vitro inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against acetylcholinesterase as a prodrug was demonstratedMore data for this Ligand-Target Pair
Affinity DataIC50: 4.67E+3nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:In vitro inhibitory activity of the compound against acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for its inhibitory concentration against Horse serum ButyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:In vitro inhibitory concentration of the compound against butyrylcholinesterase (BuChE) obtained from rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Pacific electric ray)
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californicaMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of [3H]-N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:In vitro inhibition of human butryl cholinesterase.More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Binding affinity of the compound against mouse muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]-pirenzepineMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:In vitro inhibition of human acetylcholinesterase.More data for this Ligand-Target Pair
Affinity DataIC50: 129nMAssay Description:Inhibitory activity against Butyrylcholinesterase in cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against Acetylcholinesterase in erythrocyteMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against Acetylcholinesterase in electric eelMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:In vitro inhibitory activity against acetylcholinesterase from electric eelMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to muscarinic acetylcholine receptor M1 of mouse cerebral cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:In vitro inhibitory effect on rat AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of Acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against acetylcholine esterase (AChE)More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:In vitro inhibitory activity against human acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellm...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Pacific electric ray)
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Istituto Di Strutturistica Chimica G. Giacomello
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate after 120 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of equine serum BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californicaMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 857nMAssay Description:Inhibition of horse BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of electric eel AChE by modified Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 857nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 30 mins before substrate addition measured after 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: 850nMAssay Description:Inhibition of BChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 30 mins before substrate addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human plasma BuchE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of electric eel AchE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 275nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assayMore data for this Ligand-Target Pair