BDBM771405 salt ::US12415797, Compound 12

SMILES Cc1nc2c(F)cc(-c3nc(Nc4cc(C(=O)NO)ccn4)ncc3F)cc2n1C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 771405   

TargetHistone deacetylase 6(Human)
Hangzhou Innogate Pharma Co.

US Patent
LigandPNGBDBM771405(salt | US12415797, Compound 12)
Affinity DataIC50: 55nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma Co.

US Patent
LigandPNGBDBM771405(salt | US12415797, Compound 12)
Affinity DataIC50: 55nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Hangzhou Innogate Pharma Co.

US Patent
LigandPNGBDBM771405(salt | US12415797, Compound 12)
Affinity DataIC50: 55nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Hangzhou Innogate Pharma Co.

US Patent
LigandPNGBDBM771405(salt | US12415797, Compound 12)
Affinity DataIC50: 300nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma Co.

US Patent
LigandPNGBDBM771405(salt | US12415797, Compound 12)
Affinity DataIC50: 750nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent