BDBM10021 (3-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl) sulfamate::JMC503540 Compound 6::YM511-based dual aromatase-sulfatase inhibitor (DASI) 8::dual aromatase-sulfatase inhibitor 8

SMILES NS(=O)(=O)Oc1cccc(CN(c2ccc(cc2)C#N)n2cnnc2)c1

InChI Key InChIKey=JMRUCVUWADOSJK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10021   

TargetAromatase(Homo sapiens (Human))
University of Bath

LigandPNGBDBM10021((3-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50:  39nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University of Bath

LigandPNGBDBM10021((3-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50:  5.13E+3nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bath

LigandPNGBDBM10021((3-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50:  39nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
University of Bath

LigandPNGBDBM10021((3-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]m...)
Affinity DataIC50:  5.13E+3nMpH: 7.5 T: 2°CAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed