BDBM100364 US10189794, Compound I-208::US10618902, Compound I-208::US9695132, I-208

SMILES COc1c(Cl)c(N2Cc3cnc(NC4COCC4NC(=O)C=C)nc3N(C)C2=O)c(Cl)c(OC)c1OC

InChI Key InChIKey=FXANRNBSMFPESM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 100364   

TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM100364(US10189794, Compound I-208 | US10618902, Compound ...)
Affinity DataIC50:  750nMpH: 7.5Assay Description:Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM100364(US10189794, Compound I-208 | US10618902, Compound ...)
Affinity DataIC50: >5.00E+3nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM100364(US10189794, Compound I-208 | US10618902, Compound ...)
Affinity DataIC50:  750nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 7, was prepared as described below...More data for this Ligand-Target Pair
In DepthDetails US Patent