BDBM102263 US8530648, 200

SMILES O=C1CCCC2(CCN(CC2)c2cnc3ccccc3n2)N1Cc1ccccc1

InChI Key InChIKey=OYVQUEIDYQCADD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 102263   

TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM102263(US8530648, 200)
Affinity DataKi:  161nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM102263(US8530648, 200)
Affinity DataKi:  589nMAssay Description:Antagonist activity at human OX2 receptor expressed in HEK cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM102263(US8530648, 200)
Affinity DataKi:  1.44E+3nMpH: 7.4Assay Description:FLIPR assay using orexin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM102263(US8530648, 200)
Affinity DataKi:  1.48E+3nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed