BDBM10344 (S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione::1-[(2-fluorophenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione::Azetidine Isatin Analogue 18f

SMILES Fc1ccccc1CN1C(=O)C(=O)c2cc(ccc12)S(=O)(=O)N1CC[C@H]1COc1ccccc1

InChI Key InChIKey=GCQVILHNVZSRTL-SFHVURJKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 10344   

TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50:  9.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50:  26nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50:  9.33nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Human)
Washington University

LigandPNGBDBM10344((S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidin...)
Affinity DataIC50: >1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed