BDBM103748 US8551978, I-15::US9394275, I-15::US9572802, Compound I-15::US9682957, I-15

SMILES CN(CCCCC(=O)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1C)C(=O)CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1

InChI Key InChIKey=AFEIULHOTSQERY-RWYGWLOXSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 103748   

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay using muscarinic receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataKi:  0.100nM ΔG°:  -14.2kcal/moleT: 37°CAssay Description:Displacement assays for determination of Ki values of test compounds were performed with [3H]-NMS at 1 nM and eleven different test compound concentr...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataKi:  0.100nMAssay Description:compounds were performed with [3H]NMS at 1 nM and eleven different test compound concentrations. The test compounds were initially dissolved to a con...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Theravance

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 μL. CHO ce...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBeta-2 adrenergic receptor(Human)
Theravance Respiratory

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataEC50:  1nMT: 25°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBeta-2 adrenergic receptor(Human)
Theravance Respiratory

US Patent
LigandPNGBDBM103748(US8551978, I-15 | US9394275, I-15 | US9572802, Com...)
Affinity DataEC50:  1nMT: 37°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent