BDBM10404 (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6,8,10(17),15-tetraen-14-ol::CHEMBL659::GALANTAMINE HYDROBROMIDE::Galantamin::Galanthamine::Galanthamine, 12::Lycoremine::Nivalin::Nivaline::Razadyne::Reminyl::US11643395, Compound 10::US9586925, Galantamine::galantamine
SMILES COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
InChI Key InChIKey=ASUTZQLVASHGKV-JDFRZJQESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 342 hits for monomerid = 10404
Affinity DataKi: 62nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 62nMAssay Description:Inhibition of human AChE assessed as acetylthiocholine hydrolysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University Of Karachi
University Of Karachi
Affinity DataKi: 190nM ΔG°: -9.32kcal/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
Affinity DataKi: 192nMAssay Description:Inhibition of human recombinant BChE using acetylthiocholine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 193nMAssay Description:Inhibition of human BChE assessed as acetylthiocholine hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of AChE by Ellman's assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 370nMAssay Description:Competitive inhibition of electric eel AChE assessed as inhibition constant for enzyme inhibitor complex preincubated for 20 mins followed by acetylt...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 370nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and m...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measu...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 428nMAssay Description:Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Inhibitory activity against AChE from electric eelMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 450nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 540nMAssay Description:Competitive inhibition of Electrophorus electricus acetylcholinesterase in presence of varying acetylthiocholine iodide substrate level preincubated ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 540nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 20mins before the addition of substrate by E...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 540nMAssay Description:Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrat...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 540nMAssay Description:Mixed inhibition of electric eel AChE using acetylcholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured ev...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 540nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellm...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 1.06E+3nMAssay Description:Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 1.56E+3nMAssay Description:Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometryMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 2.07E+3nMAssay Description:Competitive inhibition of equine serum butyrylcholinesterase in presence of varying butyrylthiocholine iodide substrate level preincubated for 20 min...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 3.00E+3nMAssay Description:Inhibition of electric eel AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine iodide as substrate measured f...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 4.24E+3nMAssay Description:Competitive inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition meas...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 7.70E+3nMAssay Description:Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured...More data for this Ligand-Target Pair
Affinity DataKi: 8.00E+3nMAssay Description:Inhibitory activity against BuChE from horse serumMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 9.37E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20mins before the addition of substrate by Ellman's met...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 9.37E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 20 mins measured for 1 min interval for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataKi: 2.15E+4nMAssay Description:Mixed inhibition of equine serum BChE using varying levels of butyrylcholine chloride as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.15E+4nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
Affinity DataKi: 2.83E+4nMAssay Description:Inhibition of BChE (unknown origin) pre-incubated for 15 mins before S-butyrylthiocholine chloride substrate addition and measured after 30 mins by c...More data for this Ligand-Target Pair
Affinity DataKi: 3.20E+4nM ΔG°: -6.23kcal/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Istituto Italiano Di Tecnologia
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of horse serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University Of Karachi
University Of Karachi
Affinity DataIC50: 418nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 614nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University Of Karachi
University Of Karachi
Affinity DataIC50: 360nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of AChE activity was determined by the spectroscopic method of Ellman using acetylthiocholine iodide as substrate, in 96-well microtiter p...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BuChE activity was determined by the spectroscopic method of Ellman using butyrylthiocholine iodide as substrate, in 96-well microtiter...More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:AChE and BChE inhibiting activities were measured in vitro by a modified spectrophotometric method previously developed by Ellman et. al.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:The reaction mixture containing phosphate buffer, AChE or BChE and chosen compounds was prepared and intensively stirred. In given times (5, 10, 15, ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.96E+3nMAssay Description:The reaction mixture containing phosphate buffer, AChE or BChE and chosen compounds was prepared and intensively stirred. In given times (5, 10, 15, ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 2.41E+3nMpH: 8.0Assay Description:The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+4nMpH: 8.0Assay Description:The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 665nMpH: 7.7Assay Description:In brief, reaction mixture composed of 10 µL of test sample of five different concentrations, 145 µL phosphate buffer 200 mM (pH 7.7), 80 µL of dithi...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:The inhibition assay of these compounds for AChE (electrophorus electricus) and BuChE (equine serum) were determined by the spectroscopic method desc...More data for this Ligand-Target Pair