BDBM10649 1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}thiophen-2-yl)ethan-1-one::2-purine deriv. 14

SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(s1)C(C)=O

InChI Key InChIKey=NGDPEZQIMUFAOC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10649   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  3.20E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  4.90E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed