BDBM106870 US8592455, 70

SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

InChI Key InChIKey=VRQXRVAKPDCRCI-UHFFFAOYSA-N

Data  9 KI  78 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 91 hits for monomerid = 106870   

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of PIM1 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of PIM3 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <1nMAssay Description:Inhibition of PIM1 (unknown origin) using Bad peptide NH2-AGAGRSRHSSYPAGT-OH as substrate measured after 10 mins in presence of ATP by luciferase-luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <1nMAssay Description:Inhibition of PIM1 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 2nMpH: 7.5Assay Description:The activity of PIM1, PIM2, and PIM3 is measured using a luciferase-luciferin based ATP detection reagent to quantify ATP depletion resulting from ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <3nMAssay Description:Inhibition of PIM2 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <3nMAssay Description:Inhibition of PIM3 kinase (unknown origin) using NH2-AGAGRSRHSSYPAGT-OH as substrate by kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <3nMAssay Description:Inhibition of PIM3 (unknown origin) using Bad peptide NH2-AGAGRSRHSSYPAGT-OH as substrate measured after 10 mins in presence of ATP by luciferase-luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataKi: <3nMAssay Description:Inhibition of PIM2 (unknown origin) using Bad peptide NH2-AGAGRSRHSSYPAGT-OH as substrate measured after 10 mins in presence of ATP by luciferase-luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase pim-3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase pim-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 18nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase pim-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal 6His-tagged human PIM-1 (29 to 313 residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of PKN1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI4Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of VPS34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCOUP transcription factor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CAMK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHB4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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