BDBM109236 WEHI-539

SMILES NCc1ccc(OCCCc2sc(nc2C(O)=O)-c2ccc3CCCC(=NNc4nc5ccccc5s4)c3c2)cc1

InChI Key InChIKey=JKMWZKPAXZBYEH-UHFFFAOYSA-N

Data  6 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 109236   

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50:  1.10nMpH: 7.4 T: 25°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 25°CAssay Description:Each 384-well plate was prepared with 4.75 µL of working assay buffer (50 mM HEPES, 10 mM DTT, 100 mM NaCl, 0.05% Tween029 and 0.1 mg/mL casein,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50: >1.20E+4nM Kd: >550nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetApoptosis regulator Bcl-2(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50: >1.20E+4nM Kd: >750nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBcl-2-like protein 2(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50:  4.10E+3nM Kd: >550nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
Walter and Eliza Hall Institute of Medical Research

LigandPNGBDBM109236(WEHI-539)
Affinity DataIC50:  7.10nM Kd:  1.40nMpH: 7.4Assay Description:The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)