BDBM111373 US8614253, 32-9::US8614253, 42-6::US9241942, 32-9::US9493435, 169
SMILES Oc1ccc2cc(ccc2c1C=O)-c1cccc(n1)C(=O)NCCN1CCOCC1
InChI Key InChIKey=SFKMLARWZZEPAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 111373
Affinity DataIC50: 48nMpH: 7.5 T: 30°CAssay Description:IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for ...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMpH: 7.5 T: 30°CAssay Description:IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for ...More data for this Ligand-Target Pair
TargetGlutathione S-transferase P/Serine/threonine-protein kinase/endoribonuclease IRE1(Human)
Mannking
US Patent
Mannking
US Patent
Affinity DataIC50: <100nMpH: 7.5 T: 30°CAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) obtained from a 500 ml baculovirus-infected ins...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMpH: 7.5Assay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) was obtained from a 500 ml baculovirus-infected i...More data for this Ligand-Target Pair
Affinity DataEC50: 6.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMpH: 7.5Assay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) was obtained from a 500 ml baculovirus-infected i...More data for this Ligand-Target Pair