BDBM112777 NORTRIPTYLINE::US8629135, SW-02

SMILES [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12

InChI Key InChIKey=UDDYRZAAZAXGQW-UHFFFAOYSA-N

Data  44 KI  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 70 hits for monomerid = 112777   

TargetAlpha-1A adrenergic receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 0.0400nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 0.0500nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  0.990nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  1.49nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  4.37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  6.30nMAssay Description:Compound was evaluated for its binding affinity towards human NET (norepinephrine) transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  8.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  8.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  8.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  60.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  60.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  84nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  97nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  148nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  148nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2011
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  197nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  279nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  294nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  317nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  1.14E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Queen'S University At Kingston

US Patent
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 1.50E+3nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetCytochrome P450 2D26(Rat)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  2.03E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  2.57E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Queen'S University At Kingston

US Patent
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:Approximately 5-20 μg of purified GST-RET proteins were incubated with 1 mM ATP in 20 μL kinase buffer (10 mM Tris-HCl, 5 mM MgCl2, pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2014
Entry Details
US Patent

LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2011
Entry Details
PubMed
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