BDBM12753 N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(3-carbamimidoylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3b

SMILES NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2ccccc12)C(F)(F)F

InChI Key InChIKey=TWBHVKYRNOGUJS-UHFFFAOYSA-N

Data  3 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12753   

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM12753(N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(...)
Affinity DataKi:  0.100nM ΔG°:  -13.5kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM12753(N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(...)
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant human factor 9a using MS-D-HHT-Gly-Arg-pNA as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
TargetCoagulation factor IX(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM12753(N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(...)
Affinity DataKi:  13nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair