BDBM130909 US10683289, Example Staurosporine::US10927120, Compound staurosporine::US8822500, Stauro- sporine::US9920060, Staurosporine

SMILES CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=HKSZLNNOFSGOKW-UHFFFAOYSA-N

Data  13 IC50

PDB links: 89 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 130909   

TargetSerine/threonine-protein kinase receptor R3(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.36nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInsulin-like growth factor 1 receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  71.5nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInsulin receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  36.4nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.41nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.18nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetNT-3 growth factor receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  0.525nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Gi Therapeutics

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  37.5nMAssay Description:For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  2.19nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetHepatocyte growth factor receptor(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  107nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetReceptor tyrosine-protein kinase erbB-2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  63nMAssay Description:For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  55nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue # PV4011), ATP was purchased from Sigma (Catalogue # A7699), HTRF® KinEASE™ Assay System was obtained...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gi Therapeutics

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  3.93nMAssay Description:For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  0.248nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent