BDBM13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190
SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
InChI Key InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 389 hits for monomerid = 13531
Affinity DataKd: 9.80nMAssay Description:Binding constant for full-length p38-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 9.80nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Average Binding Constant for p38-alpha; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 28nMAssay Description:Binding constant for full-length NLKMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant active p38alpha MAP kinase was tested by measuring the incorporation of 33P from gamma-[33P] ATP into myelin basic pr...More data for this Ligand-Target Pair
Affinity DataKd: 32nMAssay Description:Binding constant for full-length p38-betaMore data for this Ligand-Target Pair
Affinity DataKd: 32nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Binding constant for JNK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of His-tagged human SAPK2a/p38 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against interleukin-1 (IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
Affinity DataKd: 51nMAssay Description:Average Binding Constant for JNK3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 59nMAssay Description:Binding constant for full-length CSNK1DMore data for this Ligand-Target Pair
Affinity DataKd: 59nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of p38-beta MAP kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged human SAPK2b/p38b2 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Average Binding Constant for p38-beta; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 120nMAssay Description:Average Binding Constant for JNK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Binding constant for RIPK2 kinase domainMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Binding constant for full-length CSNK1EMore data for this Ligand-Target Pair
Affinity DataKd: 210nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for full-length JNK2More data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for EGFR(E746-A750del) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 270nMAssay Description:Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant p38alpha assessed as [gamma33P]ATP utilization by microplate scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 350nMAssay Description:Average Binding Constant for RIPK2; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 400nMAssay Description:Average Binding Constant for CSNK1E; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 510nMAssay Description:Binding constant for CIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 510nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit beta(Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 530nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit beta(Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 530nMAssay Description:Binding constant for full-length PKAC-betaMore data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:Binding constant for BRAF(V600E) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 640nMAssay Description:Binding constant for DMPK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 640nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 650nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 790nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 790nMAssay Description:Binding constant for STK36 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 910nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
