BDBM14159 APC-11421::CHEMBL62897::N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide::N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide

SMILES [H]/N=C(\c1ccc(cc1Cl)NC(=O)c2cc(cc(c2O)I)C)/N

InChI Key InChIKey=QKGFTDAISIBIBV-UHFFFAOYSA-N

Data  11 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14159   

TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  6.00E+3nM ΔG°:  -7.05kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi: >7.50E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi: >7.50E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  2.10E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  2.40E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  1.10E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  1.10E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  2.45E+5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  2.56E+5nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14159(N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iod...)
Affinity DataKi:  1.15E+5nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed