BDBM142369 US8933221, 10

SMILES c1cc(c(cc1F)F)[C@]23COCC[C@H]2CSC(=N3)N

InChI Key InChIKey=CUNQNADGWRXYCV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142369   

TargetBeta-secretase 1(Human)
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50: 265nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50: 5.10E+3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CatD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed