BDBM168144 US10865186, Compound 4::US9688638, 4::US9688638, 5::US9688638, 6
SMILES COCCOCCOCCOc1ccc2C(=O)[C@@H]3[C@H](C)[C@](C)(CCN3CC3CC3)c2c1
InChI Key InChIKey=XABOZBYZMXKFLG-WYRQLCSISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 168144
Affinity DataKi: 203nM ΔG°: -9.12kcal/mole IC50: 879nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Affinity DataKi: 203nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Affinity DataKi: 1.40E+3nM ΔG°: -7.98kcal/mole IC50: 6.08E+3nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Affinity DataKi: 2.96E+3nM ΔG°: -7.54kcal/mole IC50: 1.28E+4nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
Affinity DataIC50: 879nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
Affinity DataEC50: 357nMAssay Description:Inhibition of cAMP accumulation by select compounds was measured in forskolin-stimulated CHO-K1 cells stably expressing KOR. CHO-K1 cells stably expr...More data for this Ligand-Target Pair
Affinity DataEC50: 350nMAssay Description:Inhibition of cAMP accumulation by select compounds was measured in forskolin-stimulated CHO-K1 cells stably expressing KOR. CHO-K1 cells stably expr...More data for this Ligand-Target Pair
Affinity DataEC50: 9.35nMAssay Description:Inhibition of cAMP accumulation by select compounds was measured in forskolin-stimulated CHO-K1 cells stably expressing KOR. CHO-K1 cells stably expr...More data for this Ligand-Target Pair