BDBM174838 US9115061, I

SMILES Cc1cc2c(C(=O)Cc3ccccc3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)Cc3ccccc3)c(O)c(O)cc2c1O

InChI Key InChIKey=IDXSKODLTDOMPF-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 174838   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKi:  190nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged Bcl-xL (unknown origin) preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKi:  360nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged Bcl2 (unknown origin) after 2 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKi:  520nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged MCl-1 (unknown origin) after 2 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataIC50:  190nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM174838(US9115061, I)
Affinity DataKd:  170nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In DepthDetails US Patent