BDBM174838 US9115061, I
SMILES Cc1cc2c(C(=O)Cc3ccccc3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)Cc3ccccc3)c(O)c(O)cc2c1O
InChI Key InChIKey=IDXSKODLTDOMPF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 174838
Affinity DataKi: 190nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged Bcl-xL (unknown origin) preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataKi: 360nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged Bcl2 (unknown origin) after 2 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University
Curated by ChEMBL
Tsinghua University
Curated by ChEMBL
Affinity DataKi: 520nMAssay Description:Inhibition of Flu-BakBH3 peptide binding to GST-tagged MCl-1 (unknown origin) after 2 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
Affinity DataKd: 170nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair