BDBM1779 CHEMBL392106::US8481733, Comparator 2

SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)C1CCC1

InChI Key InChIKey=CUUVDXRUAQXJBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1779   

TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Osi Pharmaceuticals

US Patent
LigandPNGBDBM1779(CHEMBL392106 | US8481733, Comparator 2)
Affinity DataIC50: >1.00E+4nMAssay Description:AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM1779(CHEMBL392106 | US8481733, Comparator 2)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of human recombinant full length IGF1R expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM1779(CHEMBL392106 | US8481733, Comparator 2)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM1779(CHEMBL392106 | US8481733, Comparator 2)
Affinity DataIC50:  606nMAssay Description:Inhibition of human recombinant GST-IGF1R activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed