BDBM179283 US9125915, compound 6

SMILES COC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1

InChI Key InChIKey=GGRCIHACOIMRKY-HNNXBMFYSA-N

Data  2 KI  3 IC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 179283   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataKi:  17nMAssay Description:Inhibition of human N-terminal His6-tagged BRD4 BD1-BD2 (57 to 550 residues) expressed in EScherichia coli BL21(DE3) after 1 hr by Alexa-647-conjugat...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataKi:  17nMAssay Description:Binding affinity to His-tagged BRD4 BD1-BD2 (K57 to K550 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of adenosine A3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataIC50:  400nMAssay Description:Inhibition of peripheral-type benzodiazepine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4/Histone H4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM179283(US9125915, compound 6)
Affinity DataIC50:  18.2nMT: 2°CAssay Description:An expression vector containing cDNA of BRD2, 3 and 4 added with Flag-tag was transfected to CHO cell, and a cell lysate was prepared 24 hr later. Bi...More data for this Ligand-Target Pair