BDBM191604 8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol (N10)

SMILES Cn1cnc(c1)-c1nccc2c(O)nc(OCCCC(F)(F)F)nc12

InChI Key InChIKey=GVIVKUKLHYWHES-UHFFFAOYSA-N

Data  9 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 191604   

TargetLysine-specific demethylase 5B [1-755](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50: >3.20E+4nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C [1-789](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50: >2.20E+5nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D [1-760](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50: >2.00E+5nMT: 2°CAssay Description:For inhibition assays, powders of inhibitor compounds were dissolved in 100% (v/v) DMSO to give a 20 or 50 mM concentration and stored at -20 °C unti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-588](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataKd: >4.00E+4nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5B [1-604](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataKd: >3.00E+4nMAssay Description:ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50:  5.00E+3nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50:  3.80E+3nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged Tev-KDM4C (1 to 366 residues) (unknown origin) using K3K9me3 as substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191604(8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...)
Affinity DataIC50:  1.90E+3nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB