BDBM202379 US10081606, Compound I-11::US9238629, I-11::US9765038, Compound I-11
SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1OC
InChI Key InChIKey=XTEXGVCQXOYDOW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 202379
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research
US Patent
Celgene Avilomics Research
US Patent
Affinity DataEC50: 55nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-745,751-967](Homo sapiens (Human))
Celgene Avilomics Research
US Patent
Celgene Avilomics Research
US Patent
Affinity DataEC50: 300nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and
EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif.,
1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research
US Patent
Celgene Avilomics Research
US Patent
Affinity DataIC50: <1nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and
EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif.,
1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research
US Patent
Celgene Avilomics Research
US Patent
Affinity DataIC50: <1nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-249,301-1210,T790M,L858R](Homo sapiens (Human))
Celgene Car
US Patent
Celgene Car
US Patent
Affinity DataEC50: >1.00E+3nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair