BDBM208267 US9265773, 2

SMILES CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4c(F)cccc34)-c2n1)-c1ccc(F)cc1

InChI Key InChIKey=GOHCXBUFLQKEIO-UHFFFAOYSA-N

Data  2 IC50  20 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 208267   

TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM208267(US9265773, 2)
Affinity DataIC50:  1.60nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1nMAssay Description:Non-nucleoside inhibition of NS5B polymerase S365A mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  7.30nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  3.90nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2B infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of NS5B polymerase C316Y mutant in HCV genotype 1A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.10nMAssay Description:Inhibition of NS5B polymerase S365A mutant in HCV genotype 1A infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 2a infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.20nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in HuH7 cells after 40 hrs by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1a infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1b infected in human HuH7 replicon cells after 72 hrs in presence of 10% FB...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  27nMAssay Description:Inhibition of NS5B polymerase E1202G/T1280I/S2197P mutant in HCV genotype 1b infected in human HuH7 replicon cells after 72 hrs in presence of 50% hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.60nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.20nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  7.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  3.90nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 2b by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.80nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 3a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  1.20nMAssay Description:Non-nucleoside inhibition of NS5B polymerase in HCV genotype 4a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Merck

Curated by ChEMBL
LigandPNGBDBM208267(US9265773, 2)
Affinity DataEC50:  2.30nMAssay Description:Non-nucleoside inhibition of NS5B polymerase C316Y mutant in HCV genotype 1a by Taqman probe based RT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein(HCV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM208267(US9265773, 2)
Affinity DataIC50:  2.70nMAssay Description:Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB