BDBM22107 7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, (+/-) 41

SMILES OC[C@H]1C[C@H](CO)N1Cc1c[nH]c2c1nc[nH]c2=O

InChI Key InChIKey=ZZDOJITUEXBERC-RKDXNWHRSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 22107   

TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  280nM ΔG°:  -8.84kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  360nM ΔG°:  -8.70kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Industrial Research

LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  580nM ΔG°:  -8.42kcal/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed