BDBM22417 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine::CHEMBL295467::LY 135252::LY 94939::LY135252::LY139602::Nisoxetine::Nisoxetine Inhibitor::US9944618, Compound ID No. 177::[3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine::[3H]Nisoxetine
SMILES CNCCC(Oc1ccccc1OC)c1ccccc1
InChI Key InChIKey=ITJNARMNRKSWTA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 64 hits for monomerid = 22417
Affinity DataKi: 1.30nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.40nMAssay Description:Invitro competitive binding versus [3H]-citalopram in murine kidney cells transfected with cDNA for human serotonin transporter (SERT)More data for this Ligand-Target Pair
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-nisoxetine from NET in Sprague-Dawley rat brain prefrontal cortex incubated for 180 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -11.7kcal/molepH: 7.4 T: 37°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Bovine)
The University of Queensland
Curated by PDSP Ki Database
The University of Queensland
Curated by PDSP Ki Database
TargetTransporter(Rat)
National Institutes of Drug Abuse - Intramural Research Program
Curated by ChEMBL
National Institutes of Drug Abuse - Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 9.90nMAssay Description:Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Invitro competitive binding versus [N-methyl-3H]-WIN 35428 in murine kidney cells transfected with cDNA for human dopamine transporter (DAT)More data for this Ligand-Target Pair
Affinity DataKi: 54.4nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
Affinity DataKi: 82.5nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
Affinity DataKi: 203nMAssay Description:Binding affinity for serotonin transporter expresed in LCK PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 277nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for dopamine transporter expressed in LCK PK1 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Mouse)
National Institutes of Health
Curated by PDSP Ki Database
National Institutes of Health
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Binding affinity against serotonin transporter (SERT) by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataIC50: >500nMAssay Description:Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar ratsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.10nMAssay Description:Binding affinity to human wild type NET expressed in african green monkey COS1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT in human HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of dopamine uptake at human DAT in human HEK293 cellsMore data for this Ligand-Target Pair