BDBM22418 Cocaine::Cocaine (-)::methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate::methyl (1R,2R,3S,5S)-8-methyl-3-[(phenylcarbonyl)oxy]-8-azabicyclo[3.2.1]octane-2-carboxylate
SMILES COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c1ccccc1)N2C
InChI Key InChIKey=ZPUCINDJVBIVPJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 153 hits for monomerid = 22418
Affinity DataIC50: 65nMAssay Description:In vitro inhibitory activity towards [3H]cocaine binding to rat striatal tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataKi: 74nMAssay Description:Displacement of [3H]WIN-35428 from dopamine transporter of rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibitory activity against radioligand [3H]WIN-35428 binding at the dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of [3H]WIN-35428 binding at dopamine transporter was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Ability to inhibit binding of [3H]WIN-35428 to dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
Affinity DataKi: 95nMAssay Description:Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine transporter (DAT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
Affinity DataKi: 96nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]3-beta-(p-fluorophenyl)tropane-2beta-carboxylic acid methyl ester [3H]7a binding to Dopamine transporter of rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatal membrane dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]WIN-35428l binding to Dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]WIN-35248 binding to the dopamine transporter in rat striatal membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatal membrane dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of [3H]3-beta-(p-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to Dopamine transporter in rat striatal membranes.More data for this Ligand-Target Pair
Affinity DataKi: 108nMAssay Description:Inhibition of [3H]-NE uptake evaluated at the monoamine transporter (NET)More data for this Ligand-Target Pair
Affinity DataKi: 108nMAssay Description:Inhibition of [3H]-NE reuptake at Norepinephrine transporter in rat parietal/occipital cortexMore data for this Ligand-Target Pair
Affinity DataKi: 108nMAssay Description:Ability to inhibit reuptake of norepinephrine ([3H]NE) at norepinephrine transporter of rat parietal/occipital regionMore data for this Ligand-Target Pair
Affinity DataKi: 108nMAssay Description:Displacement of [3H]NE from Norepinephrine transporter of rat brainMore data for this Ligand-Target Pair
Affinity DataKi: 108nMAssay Description:Compound was tested for its ability to inhibit high-affinity uptake of [3H]NE into parietal and occipital cortex in ratMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 139nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 139nMAssay Description:Competitive inhibition against [3H]cocaine binding to cocaine receptor in bovine striatal tissueMore data for this Ligand-Target Pair
Affinity DataKi: 146nMAssay Description:Displacement of [3H]WIN-35248 from dopamine transporter (DAT) of rat striatal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:Ability to inhibit reuptake of serotonin ([3H]5-HT) at serotonin transporter of rat midbrianMore data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:Inhibition of [3H]-5-HT uptake evaluated at the Serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:Displacement of [3H]5-HT from serotonin transporter of rat brainMore data for this Ligand-Target Pair
Affinity DataKi: 155nMAssay Description:Inhibition of [3H]5-HT reuptake at serotonin transporter in rat mid brainMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Compound was tested for its ability to inhibit high affinity uptake of [3H]5-HT into mid brain nerve endings (synaptosomes) in ratMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Inhibition of [3H]5-HT uptake at Serotonin transporter in rat mid brainMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Inhibition of [3H]5-HT uptake at striatal nerve endings by serotonin transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:The compound was tested for inhibition of [3H]norepinephrine uptake in HEK cells by expressing cDNA for human norepinephrine transporterMore data for this Ligand-Target Pair
Affinity DataKi: 186nMAssay Description:Inhibition of [3H]NE binding to norepinephrine transporter of rat brain synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 187nMAssay Description:Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissueMore data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Inhibition of [3H]NE uptake at Norepinephrine transporter in rat parietal/occipital cortex was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 192nMAssay Description:Inhibition of [3H]norepinephrine uptake in HEK cells expressing human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Bovine)
The University of Queensland
Curated by PDSP Ki Database
The University of Queensland
Curated by PDSP Ki Database
TargetSodium-dependent dopamine transporter(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of mouse DAT expressed in HEK293 cells assessed as reduction in [3H]-DA uptakeMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of DAT (unknown origin) expressed in COS7 cells assessed as reduction in [3H]DA uptake incubated for 5 mins by beta-scintillation counting...More data for this Ligand-Target Pair
Affinity DataIC50: 207nMAssay Description:Compound was tested for binding affinity to Serotonin transporter sites in homogenates prepared from rat cortical membranes using [3H]paroxetine as r...More data for this Ligand-Target Pair
Affinity DataIC50: 221nMAssay Description:Inhibition of recombinant human NET expressed in HEK293 cell membranes assessed as reduction in [3H]-norepinephrine uptake incubated for 22 mins by m...More data for this Ligand-Target Pair
Affinity DataIC50: 221nMAssay Description:Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as rad...More data for this Ligand-Target Pair
