BDBM224288 5-(6-(5-chloropyridin-3-yl)-7-(1- ((trans)-4-methylcyclohexyl)ethyl)- 8-((r)-3-phenylmorpholino)-7h- purin-2-yl)-1,3,4-oxadiazol-2(3h)- one::US9540377, 18.14

SMILES CC([C@H]1CC[C@H](C)CC1)n1c(nc2nc(nc(-c3cncc(Cl)c3)c12)-c1n[nH]c(=O)o1)N1CCOC[C@H]1c1ccccc1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224288   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224288(5-(6-(5-chloropyridin-3-yl)-7-(1- ((trans)-4-methy...)
Affinity DataIC50:  0.620nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent