BDBM234576 US9353089, Table 8, Compound 1

SMILES CCC(CN1C(=N)NC(C1=O)(c1ccccc1)c1ccccc1)c1ccccc1

InChI Key InChIKey=PSNGTIQWNUJCAN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 234576   

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  12nMpH: 4.5 T: 25°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  45nMpH: 4.5 T: 25°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCathepsin E(Human)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  99nMpH: 4.0 T: 25°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCathepsin D(Human)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  385nMpH: 4.0 T: 25°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetBeta-secretase 1(Human)
Saint Louis University

US Patent
LigandPNGBDBM234576(US9353089, Table 8, Compound 1)
Affinity DataIC50:  2.30E+3nMpH: 4.0 T: 25°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent