BDBM234957 4-(2-((4-(4-(1-oxa-8-azaspiro[4.5]decan-8-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-n-(cyanomethyl)benzamide::US9556148, 24
SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCC(CC2)N2CCC3(CCCO3)CC2)n1
InChI Key InChIKey=INLABPUOFFOHBG-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 234957
Affinity DataIC50: 5nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair