BDBM238345 US9388165, 1

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12

InChI Key InChIKey=JETCTCUSGZDEGL-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 238345   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  6.10nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  87nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  61nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  393nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  261nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: >2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50:  66nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent