BDBM238345 US9388165, 1

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12

InChI Key InChIKey=JETCTCUSGZDEGL-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 238345   

LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 6.10nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 61nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 66nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 87nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 261nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 393nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetInsulin-like growth factor 1 receptor(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM238345(US9388165, 1)
Affinity DataIC50: 2.50E+3nMAssay Description:In a similar manner to Experimental Example 1, the % inhibitory activity (concentration of the compound 1.0 μM) and the IC50 values of the inven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent