BDBM241949 US9428466, Merbarone

SMILES O=C(Nc1ccccc1)C1C(=O)NC(=S)NC1=O

InChI Key InChIKey=JARCFMKMOFFIGZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 241949   

TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  5.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  2.74E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of human topoisomerase 2alpha expressed in baculovirus-infected insect cells assessed as reduction in pBR322 supercoiled DNA relaxation af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 12(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human topo2alpha by plasmid relaxation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human topo2alpha incubated for 30 mins by SYBR safe DNA stain based decatenation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  2.74E+5nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 after 1 hr by ethidium bromide stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed