BDBM243992 2-((3-acetyl-3-azabicyclo[3.1.0]hexan-6-yl)amino)-n-((s)-2-hydroxy-1-phenylethyl)-5,5-dimethyl-5h-pyrrolo[3,4-d]pyrimidine-6(7h)-carboxamide::US9546173, cmpd 68

SMILES CC(=O)N1CC2C(C1)C2Nc1ncc2c(CN(C(=O)N[C@H](CO)c3ccccc3)C2(C)C)n1

InChI Key InChIKey=BZPXUEVFCJJJPP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243992   

TargetMitogen-activated protein kinase 1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 243992BDBM243992(2-((3-acetyl-3-azabicyclo[3.1.0]hexan-6-yl)amino)-...)
Affinity DataIC50: 450nMpH: 7.5Assay Description:Compound potency against activated ERK2 was determined using a kinase assay that measures ERK2-catalyzed phosphorylation of biotinylated ERKtide pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details
US Patent