BDBM25284 (1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phenyl]phenyl}-1-phosphonoethyl)phosphonic acid::BPH-675::bisphosphonate, 6

SMILES OC(Cc1cccc(c1)-c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=MZVWVRVNMXTDAK-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25284   

TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataKi:  80nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University Of California San Diego

LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataIC50:  8.20E+3nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataIC50:  2.69E+3nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair