BDBM263263 2,5-dimethyl-1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-benzyl]-1h-pyrrole-3-carboxylicacid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 44

SMILES Cc1cc(C(=O)NCc2ccc3c(N)nccc3c2)c(C)n1Cc1ccc(Cn2ccccc2=O)cc1

InChI Key InChIKey=GBMUDCZNXCHCOS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263263   

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263263(2,5-dimethyl-1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-be...)
Affinity DataIC50:  7.09E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263263(2,5-dimethyl-1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-be...)
Affinity DataIC50:  3.90nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent