BDBM263321 1-(3-phenoxy-benzyl)-1h-pyrazole-4-carboxylic acid (1h-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amide::US9533987, example 108

SMILES O=C(NCc1cnc2[nH]ccc2c1)c1cnn(Cc2cccc(Oc3ccccc3)c2)c1

InChI Key InChIKey=MHEVBBRLOVIVPI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263321   

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 263321BDBM263321(US9533987, example 108 | 1-(3-phenoxy-benzyl)-1h-p...)
Affinity DataIC50: 2.06E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 263321BDBM263321(US9533987, example 108 | 1-(3-phenoxy-benzyl)-1h-p...)
Affinity DataIC50: 2.20E+4nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent