BDBM263944 2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonicotinic acid::US10173996, Example 14::US9604961, Example 14::US9714230, 14::US9908865, Example 14

SMILES OC(=O)c1ccnc(c1)-n1nccc1-c1ccc(F)cc1F

InChI Key InChIKey=WTMJZFIQFSYVHA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 263944   

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 170nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 380nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 263944BDBM263944(2-(5-(2,4-difluorophenyl)-1H- pyrazol-1-yl)isonico...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent