BDBM26948 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL46516::FLUSPIRILENE::NCGC00015424::cid_3396::med.21724, Compound Fluspirilene::spiropiperidine analogue, 1

SMILES Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=QOYHHIBFXOOADH-UHFFFAOYSA-N

Data  56 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 26948   

TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  0.670nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  3.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Acadia Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  8.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  9.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  56nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  62nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  102nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  151nMAssay Description:Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataEC50:  232nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  500nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  540nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  590nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetBeta-arrestin-1(Rabbit)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetProtachykinin-1(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetNeurotensin(Guinea pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.19E+3nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataEC50:  1.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataKi:  1.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
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