BDBM273069 2-(5-oxo-7-propyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)pyrazolidine-1-carboxylic acid phenyl ester::US10065972, Example 176

SMILES CCCc1cc(=O)n2nc(sc2n1)N1CCCN1C(=O)Oc1ccccc1

InChI Key InChIKey=QQHPGXZEHHNRPU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273069   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 273069BDBM273069(2-(5-oxo-7-propyl-5H-[1,3,4]thiadiazolo[3,2-a]pyri...)
Affinity DataIC50: 520nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent